Glipizide

Category: pharmacological

Aliases: Glucotrol

Pharmacological Mechanism

Second-generation sulfonylurea — closes pancreatic β-cell K-ATP channels → depolarization → Ca²⁺ influx → insulin release. Hypoglycemia risk + weight gain. CYP2C9 substrate; renal-safe relative to glyburide.

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 10mg (Range: 2.5 - 20 mg)

Target Organ Systems

• endocrine
• digestive
• renal