Ginkgolide A

Category: terpenoid

Pharmacological Mechanism

Cage-structure C20 diterpene lactone from Ginkgo biloba. Weak PAF (platelet-activating factor) antagonist relative to ginkgolide B. Component of standardized EGb 761 extract (24%/6% flavonoid/terpene spec).

Half-Life (t½)

PO: 4h

Dosing Guidelines

• PO: Typical 5 mg (Range: 1–20 mg)

Target Organ Systems

• nervous
• cardiovascular

Chemical Identifiers

• PubChem CID: 9909368
• Formula: C20H24O9
• Molecular weight: 408.4 g/mol
• InChIKey: FPUXKXIZEIDQKW-VKMVSBOZSA-N
• SMILES: C[C@@H]1C(=O)O[C@@H]2[C@]1([C@@]34C(=O)O[C@H]5[C@]3(C2)[C@@]6([C@@H](C5)C(C)(C)C)[C@H](C(=O)O[C@H]6O4)O)O