Gentamicin

Category: pharmacological

Pharmacological Mechanism

Aminoglycoside — binds bacterial 30S ribosome at A-site, causes misreading + premature chain termination. Concentration-dependent killing → once-daily extended-interval dosing. Nephrotoxicity + ototoxicity (cochlear + vestibular) require trough monitoring + audiometry.

Half-Life (t½)

IV: 2h, IM: 2h

Dosing Guidelines

• IV: Typical 240 mg (Range: 80–500 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Bacterial ribosome (inhibitor) — 30S (16S rRNA — mistranslation)

Chemical Identifiers

• PubChem CID: 3467
• Formula: C21H43N5O7
• Molecular weight: 477.6 g/mol
• InChIKey: CEAZRRDELHUEMR-UHFFFAOYSA-N
• SMILES: CC(C1CCC(C(O1)OC2C(CC(C(C2O)OC3C(C(C(CO3)(C)O)NC)O)N)N)N)NC

References

• PMID 8361865