Gentamicin

Category: pharmacological

Pharmacological Mechanism

Aminoglycoside — binds bacterial 30S ribosome at A-site, causes misreading + premature chain termination. Concentration-dependent killing → once-daily extended-interval dosing. Nephrotoxicity + ototoxicity (cochlear + vestibular) require trough monitoring + audiometry.

Half-Life (t½)

IV: 2h, IM: 2h

Dosing Guidelines

• IV: Typical 240mg (Range: 80 - 500 mg)

Target Organ Systems

• renal