Isoflavone phytoestrogen with ER-β preferential affinity. Also a tyrosine-kinase inhibitor at micromolar concentrations (basis for early anticancer interest) and a topoisomerase-II interactor. Gut microbiota metabolise genistein to dihydrogenistein and 6′-OH-O-desmethylangolensin; these metabolites vary widely between individuals.
Half-Life (t½)
PO: 10.1h
Dosing Guidelines
PO: Typical 53.3 mg (Range: 40–80 mg)
Target Organ Systems
digestive
immune-hematologic
Interactions
Daidzein (synergistic): Co-occur in soy isoflavone fractions; combined ER-β activity is the usual clinical exposure.