Category: peptide
Aliases: Orgalutran, Antagon, Org-37462
Decapeptide GnRH-R antagonist engineered with D-arginine substitutions at positions 6 and 8 to reduce mast-cell histamine release compared with first-generation GnRH antagonists (Antide etc.). Used in IVF / ART controlled ovarian stimulation to block premature LH surge. Reaches suppression rapidly (hours) and effect wanes within 24 h of last dose — smoother endocrine control than agonist protocols.
SC: 12.8h