Fulvestrant

Category: hormone

Aliases: Faslodex

Pharmacological Mechanism

Pure estrogen receptor antagonist + degrader — binds ER, blocks dimerization and DNA binding, marks ER for proteasomal degradation. IM depot for advanced ER-positive breast cancer. No agonist activity (unlike tamoxifen) → no endometrial-cancer risk.

Half-Life (t½)

IM: 1200h

Dosing Guidelines

• IM: Typical 500mg (Range: 250 - 500 mg)

Target Organ Systems

• endocrine
• reproductive