Fosinopril

Category: pharmacological

Aliases: Monopril

Pharmacological Mechanism

ACE inhibitor prodrug — phosphinic acid moiety distinguishes it. Dual hepatic + renal clearance (only ACEi with this — others are predominantly renal) → no dose adjustment in mild renal impairment.

Half-Life (t½)

PO: 12h

Dosing Guidelines

• PO: Typical 20 mg (Range: 10–80 mg)

Target Organ Systems

• cardiovascular
• digestive
• renal

Pathways It Modulates

• Bradykinin / kallikrein-kinin system (inhibitor) — ACE (phosphinate; dual renal+hepatic elimination)
• Renin-angiotensin-aldosterone axis (inhibitor) — ACE

Chemical Identifiers

• PubChem CID: 9601226
• Formula: C30H46NO7P
• Molecular weight: 563.66 g/mol
• InChIKey: BIDNLKIUORFRQP-XYGFDPSESA-N
• SMILES: CCC(=O)O[C@H](C(C)C)O[P@](=O)(CCCCC1=CC=CC=C1)CC(=O)N2C[C@@H](C[C@H]2C(=O)O)C3CCCCC3

References

• PMID 11563407