Category: vitamin
Aliases: Vitamin B9, Pteroylmonoglutamic acid, Synthetic folate
Synthetic fully-oxidised form. Reduced in vivo by DHFR to tetrahydrofolate (see [[folate_one_carbon]]) (THF), then to 5,10-methylene-THF and 5-methyl-THF (5-MTHF). DHFR capacity is finite — unmetabolised folic acid (UMFA) appears in plasma at doses >400 mcg, with uncertain long-term significance. MTHFR C677T homozygotes convert folic acid to 5-MTHF less efficiently (rationale for [[methylfolate]] supplementation).
PO: 5h