Fluphenazine

Category: pharmacological

Aliases: Prolixin, Modecate, fluphenazine decanoate

Pharmacological Mechanism

High-potency phenothiazine (typical) antipsychotic; predominantly a D2 antagonist, also blocks 5-HT2A. Oral form has very low bioavailability (~3%, heavy first-pass); long-acting decanoate depot dosed q2–5 weeks.

Half-Life (t½)

PO: 16.4h, IM: 16.4h

Dosing Guidelines

• PO: Typical 10mg (Range: 2.5 - 40 mg)
• IM: Typical 25mg (Range: 12.5 - 100 mg)

Target Organ Systems

• nervous