Flumazenil

Category: pharmacological

Aliases: Romazicon

Pharmacological Mechanism

Competitive GABA-A benzodiazepine-site antagonist — reverses benzodiazepine sedation in overdose / procedural over-sedation. Short half-life requires re-dosing after long-acting BZD overdose. Precipitates seizures in chronic BZD users + mixed-overdose with TCAs.

Half-Life (t½)

IV: 0.7h

Dosing Guidelines

• IV: Typical 0.5mg (Range: 0.2 - 1 mg)

Target Organ Systems

• nervous