Fludrocortisone

Category: hormone

Aliases: Florinef

Pharmacological Mechanism

Potent mineralocorticoid (~125× cortisol at MR) with secondary glucocorticoid activity. Used to replace aldosterone in adrenal insufficiency and to treat orthostatic hypotension via Na+ retention in renal collecting duct.

Half-Life (t½)

PO: 3.5h

Dosing Guidelines

• PO: Typical 0.1mg (Range: 0.05 - 0.2 mg)

Target Organ Systems

• endocrine
• renal