Fexofenadine

Category: pharmacological

Aliases: Allegra

Pharmacological Mechanism

Second-generation H1 antagonist — active metabolite of terfenadine (pulled from market for QT). No CNS sedation; no QT signal. P-glycoprotein substrate (grapefruit juice lowers F).

Half-Life (t½)

PO: 3.75h

Dosing Guidelines

• PO: Typical 180mg (Range: 60 - 180 mg)

Target Organ Systems

• digestive