Fenofibrate

Category: pharmacological

Aliases: Tricor, Lipidil

Pharmacological Mechanism

PPARα agonist → increased hepatic fatty-acid oxidation + lipoprotein-lipase transcription → ~50% TG reduction + modest HDL rise. LDL effect modest. Reduces CV events in hypertriglyceridemic diabetic populations (FIELD, ACCORD-Lipid subgroups).

Half-Life (t½)

PO: 20h

Dosing Guidelines

• PO: Typical 80.3mg (Range: 48 - 145 mg)

Target Organ Systems

• cardiovascular
• digestive

Interactions

• Statins