Felodipine

Category: pharmacological

Aliases: Plendil

Pharmacological Mechanism

Dihydropyridine CCB — vascular Cav1.2 blockade > cardiac selectivity ratio higher than amlodipine. Once-daily extended-release dosing for hypertension. Grapefruit juice raises AUC ~2× via intestinal CYP3A4 inhibition (the canonical grapefruit-DDI example).

Half-Life (t½)

PO: 10.2h

Dosing Guidelines

• PO: Typical 5 mg (Range: 2.5–10 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Voltage-gated calcium channels (inhibitor) — L-type Cav1.2 (vascular)

Chemical Identifiers

• PubChem CID: 3333
• Formula: C18H19Cl2NO4
• Molecular weight: 384.25 g/mol
• InChIKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N
• SMILES: CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C

References

• PMID 41203691