Felodipine

Category: pharmacological

Aliases: Plendil

Pharmacological Mechanism

Dihydropyridine CCB — vascular Cav1.2 blockade > cardiac selectivity ratio higher than amlodipine. Once-daily extended-release dosing for hypertension. Grapefruit juice raises AUC ~2× via intestinal CYP3A4 inhibition (the canonical grapefruit-DDI example).

Half-Life (t½)

PO: 10.2h

Dosing Guidelines

• PO: Typical 5mg (Range: 2.5 - 10 mg)

Target Organ Systems

• cardiovascular
• digestive