Febuxostat

Category: pharmacological

Aliases: Uloric

Pharmacological Mechanism

Non-purine xanthine oxidase inhibitor. More potent uric acid lowering than allopurinol. CARES trial (2018) showed CV mortality signal vs allopurinol → black-box warning + reserved for allopurinol-intolerant patients.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 40mg (Range: 40 - 80 mg)

Target Organ Systems

• cardiovascular