Febuxostat

Category: pharmacological

Aliases: Uloric

Pharmacological Mechanism

Non-purine xanthine oxidase inhibitor. More potent uric acid lowering than allopurinol. CARES trial (2018) showed CV mortality signal vs allopurinol → black-box warning + reserved for allopurinol-intolerant patients.

Half-Life (t½)

PO: 7h

Dosing Guidelines

• PO: Typical 40 mg (Range: 40–80 mg)

Target Organ Systems

• cardiovascular

Pathways It Modulates

• Purine catabolism (inhibitor) — xanthine oxidase

Chemical Identifiers

• PubChem CID: 134018
• Formula: C16H16N2O3S
• Molecular weight: 316.37 g/mol
• InChIKey: BQSJTQLCZDPROO-UHFFFAOYSA-N
• SMILES: CC1=C(SC(=N1)C2=CC(=C(C=C2)OCC(C)C)C#N)C(=O)O

References

• PMID 35849446
• PMID 8243554