Ezetimibe

Category: pharmacological

Aliases: Zetia, Ezetrol

Pharmacological Mechanism

Inhibits Niemann-Pick C1-like 1 (NPC1L1) at the intestinal brush border → blocks dietary cholesterol + phytosterol absorption. Non-statin mechanism → additive LDL reduction when combined with statin. IMPROVE-IT trial established CV benefit of ezetimibe-statin combination.

Half-Life (t½)

PO: 24.3h

Dosing Guidelines

• PO: Typical 10mg (Range: 10 - 10 mg)

Target Organ Systems

• cardiovascular
• digestive

Interactions

• Atorvastatin / statins