Exemestane

Category: pharmacological

Aliases: Aromasin

Pharmacological Mechanism

Steroidal aromatase inhibitor — irreversible inactivation of CYP19A1 (vs the reversible non-steroidal AIs anastrozole + letrozole). Adjuvant or sequential therapy in postmenopausal ER-positive breast cancer.

Half-Life (t½)

PO: 24h

Dosing Guidelines

• PO: Typical 25mg (Range: 25 - 25 mg)

Target Organ Systems

• endocrine
• digestive
• reproductive