Etravirine

Category: pharmacological

Aliases: Intelence

Pharmacological Mechanism

Second-generation NNRTI — flexible binding mode active against HIV-1 with first-generation NNRTI resistance mutations. Reserved for treatment-experienced patients. CYP3A4 + CYP2C9 + CYP2C19 substrate + inducer.

Half-Life (t½)

PO: 41h

Dosing Guidelines

• PO: Typical 200 mg (Range: 200–200 mg)

Target Organ Systems

• digestive
• immune-hematologic

Pathways It Modulates

• HIV replication cycle blockade (inhibitor) — HIV-1 reverse transcriptase (NNRTI, second-generation)

Chemical Identifiers

• PubChem CID: 193962
• Formula: C20H15BrN6O
• Molecular weight: 435.28 g/mol
• InChIKey: PYGWGZALEOIKDF-UHFFFAOYSA-N
• SMILES: CC1=CC(=CC(=C1OC2=NC(=NC(=C2Br)N)NC3=CC=C(C=C3)C#N)C)C#N

References

• PMID 25975423