Etravirine

Category: pharmacological

Aliases: Intelence

Pharmacological Mechanism

Second-generation NNRTI — flexible binding mode active against HIV-1 with first-generation NNRTI resistance mutations. Reserved for treatment-experienced patients. CYP3A4 + CYP2C9 + CYP2C19 substrate + inducer.

Half-Life (t½)

PO: 41h

Dosing Guidelines

• PO: Typical 200mg (Range: 200 - 200 mg)

Target Organ Systems

• digestive
• immune-hematologic