Ethosuximide

Category: pharmacological

Aliases: Zarontin

Pharmacological Mechanism

T-type Ca²⁺ channel blocker in thalamocortical circuits — first-line for absence seizures (childhood). Doesn't treat tonic-clonic; specifically fits the spike-and-wave thalamic mechanism of absence epilepsy.

Half-Life (t½)

PO: 50h

Dosing Guidelines

• PO: Typical 500 mg (Range: 250–1500 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Voltage-gated calcium channels (inhibitor) — T-type Cav3.x (thalamic)

Chemical Identifiers

• PubChem CID: 3291
• Formula: C7H11NO2
• Molecular weight: 141.17 g/mol
• InChIKey: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• SMILES: CCC1(CC(=O)NC1=O)C

References

• PMID 8799524