Eszopiclone

Category: sleep

Aliases: Lunesta

Pharmacological Mechanism

S-enantiomer of zopiclone. GABA-A PAM with slightly less α1 selectivity than zolpidem — longer t½ → better sleep-maintenance (vs zolpidem's sleep-onset).

Half-Life (t½)

PO: 5.5h

Dosing Guidelines

• PO: Typical 1.67 mg (Range: 1–3 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• GABA-A receptor signaling (activator) — α1-selective BZD-site (Z-drug)

Chemical Identifiers

• PubChem CID: 969472
• Formula: C17H17ClN6O3
• Molecular weight: 388.81 g/mol
• InChIKey: GBBSUAFBMRNDJC-INIZCTEOSA-N
• SMILES: CN1CCN(CC1)C(=O)O[C@H]2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl

References

• PMID 1684924
• PMID 18973287