Estradiol

Category: hormone

Aliases: 17β-estradiol, E2

Pharmacological Mechanism

Primary endogenous estrogen. Activates ER-α and ER-β nuclear receptors → transcriptional regulation. Also rapid non-genomic membrane signaling. Therapeutic in menopausal HRT, gender-affirming care, and certain cancers (oral, transdermal, IM ester forms).

Half-Life (t½)

PO: 14h, TD: 14h

Dosing Guidelines

• PO: Typical 2mg (Range: 0.5 - 4 mg)
• TD: Typical 0.05mg (Range: 0.025 - 0.1 mg)

Target Organ Systems

• endocrine
• reproductive