Estradiol

Category: hormone

Aliases: 17β-estradiol, E2

Pharmacological Mechanism

Primary endogenous estrogen. Activates ER-α and ER-β nuclear receptors → transcriptional regulation. Also rapid non-genomic membrane signaling. Therapeutic in menopausal HRT, gender-affirming care, and certain cancers (oral, transdermal, IM ester forms).

Half-Life (t½)

PO: 14h, TD: 14h

Dosing Guidelines

• PO: Typical 2 mg (Range: 0.5–4 mg)
• TD: Typical 0.05 mg (Range: 0.025–0.1 mg)

Target Organ Systems

• endocrine
• reproductive

Pathways It Modulates

• Estrogen receptor (ERα / ERβ / GPER) (activator) — ERα/β + GPER (endogenous + Rx)

Chemical Identifiers

• PubChem CID: 5757
• Formula: C18H24O2
• Molecular weight: 272.38 g/mol
• InChIKey: VOXZDWNPVJITMN-ZBRFXRBCSA-N
• SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

References

• PMID 9048584