Esomeprazole

Category: pharmacological

Aliases: Nexium

Pharmacological Mechanism

S-enantiomer of omeprazole — slower CYP2C19 metabolism than the racemate gives modestly higher steady-state AUC. Same H+/K+-ATPase mechanism. CYP2C19 inhibitor (clopidogrel DDI relevant).

Half-Life (t½)

PO: 1.5h, IV: 1.5h

Dosing Guidelines

• PO: Typical 40 mg (Range: 20–40 mg)

Target Organ Systems

• digestive

Pathways It Modulates

• Gastric acid secretion (inhibitor) — H+/K+-ATPase (S-enantiomer of omeprazole)

Chemical Identifiers

• PubChem CID: 9568614
• Formula: C17H19N3O3S
• Molecular weight: 345.42 g/mol
• InChIKey: SUBDBMMJDZJVOS-DEOSSOPVSA-N
• SMILES: CC1=CN=C(C(=C1OC)C)C[S@](=O)C2=NC3=C(N2)C=C(C=C3)OC

References

• PMID 11286324