Esketamine

Category: pharmacological

Aliases: Spravato

Pharmacological Mechanism

S-enantiomer of ketamine — ~4× NMDA receptor affinity vs racemate. Intranasal formulation FDA-approved for treatment-resistant depression in conjunction with oral antidepressant. Rapid (hours) antidepressant effect; REMS for dissociation + abuse risk.

Half-Life (t½)

IN: 8h

Dosing Guidelines

Target Organ Systems