Epicatechocorynantheine A

Category: alkaloid

Pharmacological Mechanism

A corynanthean–epicatechin flavoalkaloid — a corynantheine-type indole (indoloquinolizidine) alkaloid covalently linked to an epicatechin (flavan-3-ol) unit, in the same monoterpene-indole-alkaloid class as yohimbine. Isolated from the stem bark of Corynanthe pachyceras, a botanical relative of yohimbe (Pausinystalia johimbe); occurrence in P. johimbe itself is not established. Reported to have moderate antiplasmodial activity; its receptor pharmacology is uncharacterised.

Target Organ Systems

• immune-hematologic

Notes

PubChem CID 146035642 (C37H40N2O9, MW 656.7). Isolated from Corynanthe pachyceras stem bark (PMID:32517373) — NOT confirmed in Pausinystalia johimbe. Abstract reports "moderate antiplasmodial activities" without a verbatim IC50.

Chemical Identifiers

• PubChem CID: 146035642
• Formula: C37H40N2O9
• Molecular weight: 656.7 g/mol
• InChIKey: QMUSFULTCSAQJC-PVMCJLLXSA-N
• SMILES: CC[C@@H]1[C@H](C[C@H]2C3=C(CCN2[C@H]1C4=C(C=C(C5=C4O[C@@H]([C@@H](C5)O)C6=CC(=C(C=C6)O)O)O)O)C7=CC=CC=C7N3)/C(=C\OC)/C(=O)OC

References

• PMID 32517373