Epicatechocorynantheidine

Category: alkaloid

Pharmacological Mechanism

A corynanthean–epicatechin flavoalkaloid joining a corynantheidine-type monoterpene indole alkaloid unit (the same corynanthean skeleton class as yohimbine) to an epicatechin (flavan-3-ol) unit. Isolated from the stem bark of Corynanthe pachyceras, a relative of yohimbe (Pausinystalia johimbe); occurrence in P. johimbe itself is not established. Reported to have moderate antiplasmodial activity; its receptor pharmacology is uncharacterised.

Target Organ Systems

• immune-hematologic

Notes

PubChem CID 146035606 (C37H38N2O9, MW 654.7). Isolated from Corynanthe pachyceras stem bark (PMID:32517373) — NOT confirmed in Pausinystalia johimbe. Abstract reports "moderate antiplasmodial activities" without a verbatim IC50.

Chemical Identifiers

• PubChem CID: 146035606
• Formula: C37H38N2O9
• Molecular weight: 654.7 g/mol
• InChIKey: DMTIGERKTROHBA-QDJISBFISA-N
• SMILES: C[C@@H]1[C@H]2[C@H](C[C@H]3C4=C(CCN3[C@H]2OC5=C1C6=C(C[C@H]([C@H](O6)C7=CC(=C(C=C7)O)O)O)C(=C5)O)C8=CC=CC=C8N4)/C(=C\OC)/C(=O)OC

References

• PMID 32517373