Enzalutamide

Category: pharmacological

Aliases: Xtandi

Pharmacological Mechanism

Androgen receptor antagonist — blocks AR ligand binding, AR nuclear translocation, and AR-DNA binding. Stronger than first-generation bicalutamide. Castration-resistant prostate cancer. Strong CYP3A4 inducer (auto-induces own clearance + lowers many co-medications).

Half-Life (t½)

PO: 130h

Dosing Guidelines

Target Organ Systems