Entecavir

Category: pharmacological

Aliases: Baraclude

Pharmacological Mechanism

Guanosine nucleoside analog — selective HBV polymerase inhibitor. First-line oral therapy for chronic HBV with high barrier to resistance + minimal HIV cross-activity. Renal excretion; food reduces F.

Half-Life (t½)

PO: 130h

Dosing Guidelines

• PO: Typical 0.5mg (Range: 0.5 - 1 mg)

Target Organ Systems

• renal
• immune-hematologic