Enoxaparin

Category: pharmacological

Aliases: Lovenox, LMWH

Pharmacological Mechanism

Low-molecular-weight heparin (~4500 Da average). Same antithrombin-mediated mechanism but biased toward factor Xa inhibition (Xa:IIa activity ratio ~3.8:1 vs UFH ~1:1). Predictable dose-response → no aPTT monitoring needed. Lower HIT incidence than UFH; preferred over UFH in most non-renal-failure scenarios.

Half-Life (t½)

SC: 4.5h, IV: 4.5h

Dosing Guidelines

• SC: Typical 40 mg (Range: 30–100 mg)

Target Organ Systems

• renal

Pathways It Modulates

• Coagulation cascade (inhibitor) — antithrombin → factor Xa (LMWH; Xa-selective)

Chemical Identifiers

• PubChem CID: 772
• Formula: C26H42N2O37S5
• Molecular weight: 1134.9 g/mol
• InChIKey: HTTJABKRGRZYRN-UHFFFAOYSA-N
• SMILES: CC(=O)NC1C(C(C(OC1O)COS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)OC3C(C(C(C(O3)CO)OC4C(C(C(C(O4)C(=O)O)O)O)OS(=O)(=O)O)OS(=O)(=O)O)NS(=O)(=O)O)O)OS(=O)(=O)O)O

References

• PMID 2851016