Emoxypine

Category: pharmacological

Aliases: Mexidol, Methylethylpyridinol

Pharmacological Mechanism

Structural analog of pyridoxine (B6). Proposed mechanisms: membrane-stabilising antioxidant, succinate-dehydrogenase activity, mild GABA-A modulation, mild benzodiazepine-site binding. Western evidence sparse; prescribed extensively in post-Soviet countries for stroke, anxiety, alcohol withdrawal, ischemia.

Half-Life (t½)

PO: 1.7h, IV: 1.7h

Dosing Guidelines

• PO: Typical 333 mg (Range: 125–750 mg)
• IV: Typical 333 mg (Range: 125–750 mg)
• IM: Typical 333 mg (Range: 125–750 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Reactive oxygen species (ROS) + oxidative stress (activator) — antioxidant + GABA modulation

Chemical Identifiers

• PubChem CID: 114681
• Formula: C8H11NO
• Molecular weight: 137.18 g/mol
• InChIKey: JPGDYIGSCHWQCC-UHFFFAOYSA-N
• SMILES: CCC1=C(C=CC(=N1)C)O

References

• PMID 25591654