Eluxadoline

Category: pharmacological

Aliases: Viberzi

Pharmacological Mechanism

Mixed μ + κ-opioid agonist + δ-opioid antagonist — gut-locally-restricted (poor systemic absorption). Approved for IBS-D. Pancreatitis + sphincter-of-Oddi spasm risk → contraindicated post-cholecystectomy.

Half-Life (t½)

PO: 5h

Dosing Guidelines

• PO: Typical 100mg (Range: 75 - 100 mg)

Target Organ Systems

• nervous
• digestive