Eluxadoline

Category: pharmacological

Aliases: Viberzi

Pharmacological Mechanism

Mixed μ + κ-opioid agonist + δ-opioid antagonist — gut-locally-restricted (poor systemic absorption). Approved for IBS-D. Pancreatitis + sphincter-of-Oddi spasm risk → contraindicated post-cholecystectomy.

Half-Life (t½)

PO: 5h

Dosing Guidelines

• PO: Typical 100 mg (Range: 75–100 mg)

Target Organ Systems

• nervous
• digestive

Pathways It Modulates

• GI motility + secretion (activator) — μ-opioid agonist + δ-opioid antagonist (gut-restricted)

Chemical Identifiers

• PubChem CID: 11250029
• Formula: C32H35N5O5
• Molecular weight: 569.65 g/mol
• InChIKey: QFNHIDANIVGXPE-FNZWTVRRSA-N
• SMILES: CC1=CC(=CC(=C1C[C@@H](C(=O)N(CC2=CC(=C(C=C2)OC)C(=O)O)[C@@H](C)C3=NC=C(N3)C4=CC=CC=C4)N)C)C(=O)N

References

• PMID 28674470