Duloxetine

Category: pharmacological

Aliases: Cymbalta

Pharmacological Mechanism

Balanced SERT + NET inhibition across the dose range (unlike venlafaxine's dose-dependent NE addition). Broader pain indications as a result.

Half-Life (t½)

PO: 13h

Dosing Guidelines

• PO: Typical 60 mg (Range: 30–120 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• BDNF / TrkB neurotrophic signaling (activator) — BDNF/TrkB (chronic)
• Serotonin receptor pharmacology (inhibitor) — SERT + NET
• SSRI/SNRI discontinuation syndrome (inhibitor) — SERT + NET (SNRI)

Chemical Identifiers

• PubChem CID: 60835
• Formula: C18H19NOS
• Molecular weight: 297.41 g/mol
• InChIKey: ZEUITGRIYCTCEM-KRWDZBQOSA-N
• SMILES: CNCC[C@@H](C1=CC=CS1)OC2=CC=CC3=CC=CC=C32

References

• PMID 21366359
• PMID 16506079
• PMID 11750180
• PMID 23084899