Dronabinol

Category: pharmacological

Aliases: Marinol

Pharmacological Mechanism

Synthetic Δ9-THC — same CB1/CB2 partial agonism. FDA-approved for chemotherapy-induced nausea + AIDS-related anorexia. Schedule III for the synthetic; CB1-mediated dysphoria + tachycardia limit dose escalation.

Half-Life (t½)

PO: 2.75h

Dosing Guidelines

• PO: Typical 5 mg (Range: 2.5–20 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• Endocannabinoid system (activator) — CB1 + CB2 (synthetic Δ9-THC)

Chemical Identifiers

• PubChem CID: 16078
• Formula: C21H30O2
• Molecular weight: 314.46 g/mol
• InChIKey: CYQFCXCEBYINGO-IAGOWNOFSA-N
• SMILES: CCCCCC1=CC(=C2[C@@H]3C=C(CC[C@H]3C(OC2=C1)(C)C)C)O

References

• PMID 38054364
• PMID 17641667
• PMID 25311884