Doxorubicin

Category: pharmacological

Aliases: Adriamycin

Pharmacological Mechanism

Anthracycline antineoplastic — DNA intercalation + topoisomerase II poisoning + iron-mediated ROS generation. Workhorse of breast / lymphoma / sarcoma regimens. Cumulative-dose cardiomyopathy is the dose-limiting toxicity (lifetime ceiling ~450 mg/m²).

Half-Life (t½)

IV: 30h

Dosing Guidelines

• IV: Typical 60 mg (Range: 30–90 mg)

Target Organ Systems

• immune-hematologic

Pathways It Modulates

• DNA-damage cytotoxic chemotherapy (inhibitor) — topoisomerase II (DNA-Top2 covalent complex)

Chemical Identifiers

• PubChem CID: 31703
• Formula: C27H29NO11
• Molecular weight: 543.52 g/mol
• InChIKey: AOJJSUZBOXZQNB-TZSSRYMLSA-N
• SMILES: C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](CC3=C2C(=C4C(=C3O)C(=O)C5=C(C4=O)C(=CC=C5)OC)O)(C(=O)CO)O)N)O

References

• PMID 8137342