Doxepin (antidepressant doses)

Category: pharmacological

Aliases: Sinequan

Pharmacological Mechanism

Tertiary-amine TCA — at antidepressant doses (75–300 mg) acts as a non-selective serotonin + NE reuptake inhibitor + H1 antagonist + muscarinic antagonist. Distinct from doxepin-low-dose-for-sleep entry which uses just the H1 effect at 3–6 mg.

Half-Life (t½)

PO: 15h

Dosing Guidelines

Target Organ Systems