Doxazosin

Category: pharmacological

Aliases: Cardura

Pharmacological Mechanism

Selective α1-adrenergic blocker — relaxes vascular + prostate smooth muscle. Used for hypertension (less first-line since ALLHAT showed worse HF outcomes than thiazides) + symptomatic BPH. First-dose orthostatic hypotension; bedtime dosing recommended.

Half-Life (t½)

PO: 12.6h

Dosing Guidelines

• PO: Typical 4 mg (Range: 1–16 mg)

Target Organ Systems

• cardiovascular
• renal
• reproductive

Pathways It Modulates

• Adrenergic receptor signaling (inhibitor) — α1

Chemical Identifiers

• PubChem CID: 3157
• Formula: C23H25N5O5
• Molecular weight: 451.48 g/mol
• InChIKey: RUZYUOTYCVRMRZ-UHFFFAOYSA-N
• SMILES: COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC

References

• PMID 2945688
• PMID 8905340