Doravirine

Category: pharmacological

Aliases: Pifeltro

Pharmacological Mechanism

Newer NNRTI with cleaner DDI profile (CYP3A4 substrate but minimal induction). Lower psychiatric side effect signal than efavirenz. Used in DOR/3TC/TDF (Delstrigo) once-daily regimen.

Half-Life (t½)

PO: 15h

Dosing Guidelines

• PO: Typical 100mg (Range: 100 - 100 mg)

Target Organ Systems

• digestive