Dolutegravir

Category: pharmacological

Aliases: Tivicay

Pharmacological Mechanism

HIV integrase strand-transfer inhibitor (INSTI) — blocks integration of viral DNA into host genome. High barrier to resistance; cornerstone of modern first-line ART. Modest UGT1A1 substrate; food doubles AUC.

Half-Life (t½)

PO: 14h

Dosing Guidelines

• PO: Typical 50mg (Range: 50 - 50 mg)

Target Organ Systems

• immune-hematologic