Dofetilide

Category: pharmacological

Aliases: Tikosyn

Pharmacological Mechanism

Class III antiarrhythmic — selective IKr blockade prolongs cardiac repolarization. Approved for AF rhythm control. Mandatory 3-day inpatient initiation (TdP risk during loading); strict CrCl-based dosing + numerous CYP3A4 / OCT2 inhibitor contraindications.

Half-Life (t½)

PO: 10h

Dosing Guidelines

• PO: Typical 0.5mg (Range: 0.125 - 0.5 mg)

Target Organ Systems

• digestive