Diphenoxylate / Atropine

Category: pharmacological

Aliases: Lomotil

Pharmacological Mechanism

Diphenoxylate (μ-opioid agonist with limited CNS access at therapeutic doses) + atropine (anticholinergic — added to deter abuse). Used for symptomatic diarrhea. Schedule V due to abuse-potential precedent; loperamide largely supplanted it.

Half-Life (t½)

PO: 7.24h

Dosing Guidelines

• PO: Typical 5mg (Range: 2.5 - 20 mg)

Target Organ Systems

• nervous