Dimenhydrinate

Category: pharmacological

Aliases: Dramamine

Pharmacological Mechanism

Salt of diphenhydramine + 8-chlorotheophylline — anti-motion-sickness via H1 + muscarinic blockade. OTC. Same anticholinergic burden as diphenhydramine; the theophylline component is incidental.

Half-Life (t½)

PO: 8h, IV: 8h

Dosing Guidelines

• PO: Typical 50mg (Range: 25 - 100 mg)

Target Organ Systems

• nervous
• digestive