Diltiazem

Category: pharmacological

Aliases: Cardizem

Pharmacological Mechanism

Non-dihydropyridine CCB — Cav1.2 blocker with both vascular and cardiac (AV-nodal) effects. Used for AF rate control + hypertension. Moderate CYP3A4 inhibitor → significant DDI footprint (statin myopathy, raised cyclosporine, raised carbamazepine).

Half-Life (t½)

PO: 11.2h, IV: 11.2h

Dosing Guidelines

• PO: Typical 240mg (Range: 60 - 480 mg)

Target Organ Systems

• cardiovascular
• digestive

Interactions

• Simvastatin
• Buspirone
• Midazolam
• Lovastatin