Buspirone

Category: pharmacological

Aliases: Buspar

Pharmacological Mechanism

5-HT1A partial agonist — generalized anxiety treatment without GABA-A activation, so no sedation, no abuse, no addiction. Onset over weeks like an SSRI; acute anxiety relief is poor. CYP3A4 substrate.

Half-Life (t½)

PO: 2.5h

Dosing Guidelines

• PO: Typical 30mg (Range: 5 - 60 mg)

Target Organ Systems

• nervous
• digestive