Digoxin

Category: pharmacological

Aliases: Lanoxin

Pharmacological Mechanism

Inhibits Na⁺/K⁺-ATPase → intracellular Na⁺ rise → Na⁺/Ca²⁺ exchanger reversal → intracellular Ca²⁺ rise → positive inotropy. Also enhances vagal tone → AV-node slowing (rate control in AF). Narrow therapeutic index: toxic at levels >2 ng/mL. Antidote: digoxin-immune Fab (Digibind).

Half-Life (t½)

PO: 40h, IV: 40h

Dosing Guidelines

• PO: Typical 0.167mg (Range: 0.125 - 0.25 mg)
• IV: Typical 0.167mg (Range: 0.125 - 0.25 mg)

Target Organ Systems

• immune-hematologic