Diclofenac

Category: pharmacological

Aliases: Voltaren

Pharmacological Mechanism

Acetic-acid NSAID — non-selective COX inhibitor with modest COX-2 preference. Higher cardiovascular risk than ibuprofen / naproxen. CYP2C9 substrate. Hepatotoxicity warning (~1:10,000).

Half-Life (t½)

PO: 1.92h

Dosing Guidelines

• PO: Typical 50 mg (Range: 25–75 mg)

Target Organ Systems

• cardiovascular
• digestive

Pathways It Modulates

• Arachidonic acid cascade (inhibitor) — COX-1 + COX-2

Chemical Identifiers

• PubChem CID: 3033
• Formula: C14H11Cl2NO2
• Molecular weight: 296.15 g/mol
• InChIKey: DCOPUUMXTXDBNB-UHFFFAOYSA-N
• SMILES: C1=CC=C(C(=C1)CC(=O)O)NC2=C(C=CC=C2Cl)Cl

References

• PMID 11874389