Diclofenac

Category: pharmacological

Aliases: Voltaren

Pharmacological Mechanism

Acetic-acid NSAID — non-selective COX inhibitor with modest COX-2 preference. Higher cardiovascular risk than ibuprofen / naproxen. CYP2C9 substrate. Hepatotoxicity warning (~1:10,000).

Half-Life (t½)

PO: 1.92h

Dosing Guidelines

• PO: Typical 50mg (Range: 25 - 75 mg)

Target Organ Systems

• cardiovascular
• digestive