Dexmethylphenidate

Category: stimulant

Aliases: Focalin, d-MPH

Pharmacological Mechanism

Pure d-threo methylphenidate — the pharmacologically active stereoisomer. Half the mg-dose of racemic methylphenidate for equivalent effect.

Half-Life (t½)

PO: 2.5h

Dosing Guidelines

• PO: Typical 8.33 mg (Range: 2.5–20 mg)

Target Organ Systems

• nervous

Pathways It Modulates

• Dopamine receptor signaling (inhibitor) — DAT + NET

Chemical Identifiers

• PubChem CID: 154101
• Formula: C14H19NO2
• Molecular weight: 233.31 g/mol
• InChIKey: DUGOZIWVEXMGBE-CHWSQXEVSA-N
• SMILES: COC(=O)[C@@H]([C@H]1CCCCN1)C2=CC=CC=C2

References

• PMID 10628897