Dexmedetomidine

Category: pharmacological

Aliases: Precedex

Pharmacological Mechanism

Selective α2-adrenergic agonist — sedation without respiratory depression (preserves arousability). ICU sedation alternative to benzodiazepines reduces delirium incidence; procedural sedation. Bradycardia + hypotension (especially with bolus loading).

Half-Life (t½)

IV: 2h, IN: 2h

Dosing Guidelines

• IV: Typical 0.7mcg (Range: 0.2 - 1.4 mcg)

Target Organ Systems

• nervous