Desvenlafaxine

Category: pharmacological

Aliases: Pristiq

Pharmacological Mechanism

SNRI — active O-desmethyl metabolite of venlafaxine. Bypasses CYP2D6 conversion → more consistent levels in CYP2D6 poor metabolizers. Stronger NE component at therapeutic doses than venlafaxine.

Half-Life (t½)

PO: 11h

Dosing Guidelines

• PO: Typical 50mg (Range: 50 - 100 mg)

Target Organ Systems

• nervous
• digestive