Desloratadine

Category: pharmacological

Aliases: Clarinex

Pharmacological Mechanism

Active descarboethoxy metabolite of loratadine — a third-generation H1 antagonist with the same minimal CNS penetration but cleaner pharmacokinetics. Once-daily dosing for allergic rhinitis + chronic urticaria.

Half-Life (t½)

PO: 27h

Dosing Guidelines

• PO: Typical 5mg (Range: 2.5 - 5 mg)

Target Organ Systems

• immune-hematologic