Delta-8-THC

Category: alkaloid

Aliases: delta-8, delta-8-tetrahydrocannabinol, d8-thc

Pharmacological Mechanism

Double-bond positional isomer of Δ9-THC (8,9 vs 9,10). A CB1/CB2 partial agonist with psychoactivity reported as roughly half that of Δ9-THC and a somewhat milder/clearer subjective profile. Predominantly hemp-derived-synthesized, occupying a legal gray area.

Dosing Guidelines

• INH: Typical 10 (Range: 5–25)
• PO: Typical 15 (Range: 5–40)

Target Organ Systems

• nervous

Notes

PubChem CID 638026. Occupancy SKIP: every verbatim Δ8 Ki located belongs to synthetic dimethyl/1-deoxy analogs; the parent value is table-only in Compton 1993 (PMID:8474008). No verbatim half-life (see AUTHORING_GAPS).

Chemical Identifiers

• PubChem CID: 638026
• Formula: C21H30O2
• Molecular weight: 314.5 g/mol
• InChIKey: HCAWPGARWVBULJ-IAGOWNOFSA-N
• SMILES: CCCCCC1=CC(=C2[C@@H]3CC(=CC[C@H]3C(OC2=C1)(C)C)C)O