Dantrolene

Category: pharmacological

Aliases: Dantrium

Pharmacological Mechanism

Skeletal muscle relaxant acting at the ryanodine receptor — inhibits sarcoplasmic Ca²⁺ release. First-line for malignant hyperthermia (rapid IV reversal); chronic oral use for spasticity in MS / spinal cord injury / cerebral palsy. Hepatotoxicity at chronic use.

Half-Life (t½)

PO: 15h, IV: 10h

Dosing Guidelines

Target Organ Systems