Dantrolene

Category: pharmacological

Aliases: Dantrium

Pharmacological Mechanism

Skeletal muscle relaxant acting at the ryanodine receptor — inhibits sarcoplasmic Ca²⁺ release. First-line for malignant hyperthermia (rapid IV reversal); chronic oral use for spasticity in MS / spinal cord injury / cerebral palsy. Hepatotoxicity at chronic use.

Half-Life (t½)

PO: 15h, IV: 10h

Dosing Guidelines

• PO: Typical 100 mg (Range: 25–400 mg)

Target Organ Systems

• nervous
• digestive
• musculoskeletal

Pathways It Modulates

• Skeletal muscle relaxants (inhibitor) — RYR1 (ryanodine receptor)

Chemical Identifiers

• PubChem CID: 6914273
• Formula: C14H10N4O5
• Molecular weight: 314.26 g/mol
• InChIKey: OZOMQRBLCMDCEG-VIZOYTHASA-N
• SMILES: C1C(=O)NC(=O)N1/N=C/C2=CC=C(O2)C3=CC=C(C=C3)[N+](=O)[O-]

References

• PMID 499321
• PMID 2929999